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Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release.
Bortezomib, CAS 179324-69-7, is a cell-permeable, selective, slowly reversible inhibitor of 20S proteasome β5 ChTL/chymotrypsin- over β1 CL/caspase- and β2 TL/trypsin-like activity.
Thermo Scientific™ CaptureSelect™ CH1-XL Affinity Matrix is an improved version of CaptureSelect IgG-CH1 Affinity Matrix, featuring a wider elution range (pH 3 to 4.5), increased binding capacity, and improved stability at higher pH, offered here in pre-packed format.
GSK2606414 is a cell-permeable, highly potent inhibitor of EIF2AK3/PERK (IC50 = 0.4 nM; [ATP] = 5 μM). Targets PERK in its inactive DFG conformation at the ATP-binding region.
The Apoptosis Activator VI, CD437/AHPN, also referenced under CAS 125316-60-1, modulates Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.
Thermo Scientific™ CaptureSelect™ C-tagXL Affinity Matrix is an improved version of CaptureSelect C-tag Affinity Matrix with a significantly increased binding capacity, offered here in pre-packed format.
Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.
β-Secretase Substrate IV, Fluorogenic, is a highly sensitive FRET substrate. Hydrolysis of the substrate (Leu-Asp cleavage) by β-secretase results in fluorescence enhancement.